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Showing 1 to 12 of 570 entries
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Armodafinil-induced wakefulness in animals with ventrolateral preoptic lesions.

Nature and science of sleep

Vetrivelan R, Saper CB, Fuller PM.
PMID: 24833927
Nat Sci Sleep. 2014 May 02;6:57-63. doi: 10.2147/NSS.S53132. eCollection 2014.

Armodafinil is the pharmacologically active R-enantiomer of modafinil, a widely prescribed wake-promoting agent used to treat several sleep-related disorders including excessive daytime sleepiness associated with narcolepsy, shift work sleep disorder, and obstructive sleep apnea/hypopnea syndrome. Remarkably, however, the neuronal...

An automated sleep-state classification algorithm for quantifying sleep timing and sleep-dependent dynamics of electroencephalographic and cerebral metabolic parameters.

Nature and science of sleep

Rempe MJ, Clegern WC, Wisor JP.
PMID: 26366107
Nat Sci Sleep. 2015 Sep 01;7:85-99. doi: 10.2147/NSS.S84548. eCollection 2015.

INTRODUCTION: Rodent sleep research uses electroencephalography (EEG) and electromyography (EMG) to determine the sleep state of an animal at any given time. EEG and EMG signals, typically sampled at >100 Hz, are segmented arbitrarily into epochs of equal duration...

New developments in the management of narcolepsy.

Nature and science of sleep

Abad VC, Guilleminault C.
PMID: 28424564
Nat Sci Sleep. 2017 Mar 03;9:39-57. doi: 10.2147/NSS.S103467. eCollection 2017.

Narcolepsy is a life-long, underrecognized sleep disorder that affects 0.02%-0.18% of the US and Western European populations. Genetic predisposition is suspected because of narcolepsy's strong association with HLA DQB1*06-02, and genome-wide association studies have identified polymorphisms in T-cell receptor...

Assessing narcolepsy with cataplexy in children and adolescents: development of a cataplexy diary and the ESS-CHAD.

Nature and science of sleep

Wang YG, Benmedjahed K, Lambert J, Evans CJ, Hwang S, Black J, Johns MW.
PMID: 28860883
Nat Sci Sleep. 2017 Aug 14;9:201-211. doi: 10.2147/NSS.S140143. eCollection 2017.

OBJECTIVE: The aim of this study was to qualitatively evaluate concepts for incorporation into a daily diary to capture cataplexy frequency and to assess the content validity of the Epworth Sleepiness Scale for Children and Adolescents (ESS-CHAD) in pediatric...

Sleep deprivation does not affect neuronal susceptibility to mild traumatic brain injury in the rat.

Nature and science of sleep

Caron AM, Stephenson R.
PMID: 26124685
Nat Sci Sleep. 2015 Jun 22;7:63-72. doi: 10.2147/NSS.S82888. eCollection 2015.

Mild and moderate traumatic brain injuries (TBIs) (and concussion) occur frequently as a result of falls, automobile accidents, and sporting activities, and are a major cause of acute and chronic disability. Fatigue and excessive sleepiness are associated with increased...

Chronic sleep disturbance and neural injury: links to neurodegenerative disease.

Nature and science of sleep

Abbott SM, Videnovic A.
PMID: 26869817
Nat Sci Sleep. 2016 Jan 25;8:55-61. doi: 10.2147/NSS.S78947. eCollection 2016.

Sleep-wake disruption is frequently observed and often one of the earliest reported symptoms of many neurodegenerative disorders. This provides insight into the underlying pathophysiology of these disorders, as sleep-wake abnormalities are often accompanied by neurodegenerative or neurotransmitter changes. However,...

Consumer sleep monitors: is there a baby in the bathwater?.

Nature and science of sleep

Russo K, Goparaju B, Bianchi MT.
PMID: 26604847
Nat Sci Sleep. 2015 Nov 05;7:147-57. doi: 10.2147/NSS.S94182. eCollection 2015.

The rapid expansion of consumer sleep devices is outpacing the validation data necessary to assess the potential use of these devices in clinical and research settings. Common sleep monitoring devices utilize a variety of sensors to track movement as...

A growth spurt in pediatric sleep research.

Nature and science of sleep

Lam DJ, Shea SA.
PMID: 27199573
Nat Sci Sleep. 2016 Apr 29;8:133-5. doi: 10.2147/NSS.S107420. eCollection 2016.

No abstract available.

A randomized controlled trial to validate the Alice PDX ambulatory device.

Nature and science of sleep

Nilius G, Domanski U, Schroeder M, Franke KJ, Hogrebe A, Margarit L, Stoica M, d'Ortho MP.
PMID: 28652835
Nat Sci Sleep. 2017 Jun 06;9:171-180. doi: 10.2147/NSS.S133789. eCollection 2017.

BACKGROUND: Obstructive sleep apnea (OSA) is a highly prevalent condition; however, the majority of patients remain undiagnosed. There is a potential to expand the diagnostic capacity of sleep laboratories. The study objective was to validate a portable respiratory monitoring...

Circadian regulation of metabolic homeostasis: causes and consequences.

Nature and science of sleep

McGinnis GR, Young ME.
PMID: 27313482
Nat Sci Sleep. 2016 May 27;8:163-80. doi: 10.2147/NSS.S78946. eCollection 2016.

Robust circadian rhythms in metabolic processes have been described in both humans and animal models, at the whole body, individual organ, and even cellular level. Classically, these time-of-day-dependent rhythms have been considered secondary to fluctuations in energy/nutrient supply/demand associated...

A pilot study of serotonin-1A receptor genotypes and rapid eye movement sleep sensitivity to serotonergic/cholinergic imbalance in humans: a pharmacological model of depression.

Nature and science of sleep

Biard K, Douglass AB, Robillard R, De Koninck J.
PMID: 26719734
Nat Sci Sleep. 2015 Dec 18;8:1-8. doi: 10.2147/NSS.S94549. eCollection 2016.

RATIONALE: The serotonergic and cholinergic systems are jointly involved in regulating sleep but this system is theorized to be disturbed in depressed individuals. We previously reported that cholinergic and serotonergic agents induce sleep changes partially consistent with monoamine models...

The effects of fabric for sleepwear and bedding on sleep at ambient temperatures of 17°C and 22°C.

Nature and science of sleep

Shin M, Halaki M, Swan P, Ireland AH, Chow CM.
PMID: 27217803
Nat Sci Sleep. 2016 Apr 22;8:121-31. doi: 10.2147/NSS.S100271. eCollection 2016.

The fibers used in clothing and bedding have different thermal properties. This study aimed to investigate the influences of textile fabrics on sleep under different ambient temperature (T a) conditions. Seventeen healthy young participants (ten males) underwent nine nights...

Showing 1 to 12 of 570 entries